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Cancer: Gastric (Stomach) Cancer

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Woman diagnoses her own ovarian cancer with Google search
Sadie Rance turns to internet search engine for answers after being told stomach pains and constipation were due to Irritable Bowel Syndrome
Source: Telegraph Health - February 6, 2015 Category: Consumer Health News Tags: search ovarian Irritable Bowel Syndrome Sadie Rance diagnosed Cancer Google Source Type: news

Real ‐time detection system for tumor localization during minimally invasive surgery for gastric and colon cancer removal: In vivo feasibility study in a swine model
ConclusionsWe demonstrated favorable results for a RFID system that detects the position of gastric and colon tumors in real‐time during MIS.
Source: Journal of Surgical Oncology - November 1, 2017 Category: Cancer & Oncology Authors: Won Jung Choi, Jin ‐Hee Moon, Jae Seok Min, Yong Keun Song, Seung A Lee, Jin Woo Ahn, Sang Hun Lee, Ha Chul Jung Tags: RESEARCH ARTICLE Source Type: research

Search for potential Inducible Nitric Oxide Synthase inhibitors with favorable ADMET profiles for the therapy of Helicobacter pylori infections.
CONCLUSION: The top-ranked compounds from the virtual screening workflow show promising results regarding the iNOS inhibition profile. The results evidenced the importance of the ionic bonding during docking selection, playing a crucial role in binding and positioning during ligand-target selection for iNOS. PMID: 31721712 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - November 10, 2019 Category: Chemistry Authors: Rodrigues RP, Ardisson JS, Ribeiro Gonçalves RC, Oliveira TB, Barreto da Silva V, Kawano DF, Kitagawa RR Tags: Curr Top Med Chem Source Type: research

Cellular mesenchymal epithelial transition (C-MET) gene copy number variation in gastric adenocarcinoma: A pilot search for new marker for targeted therapy in HER-2/neu resistance.
Abstract Increasing HER-2/neu resistance in gastric carcinoma has encouraged search for new biomarkers for targeted therapy. Cellular mesenchymal epithelial transition (C-MET) is one such tyrosine kinase inhibitor proposed for personalized salvage treatment. We determined frequency of C-MET gene copy number variation (CNV) by Fluorescent in-situ hybridization (FISH) in gastric adenocarcinoma (GAC) and sought its correlation with conventional clinicopathologic parameters. Dual-coloured FISH was done on 32 GAC cases. C-MET gene and centromere 7 signals were counted under fluorescent microscope and ratio was calculat...
Source: Indian Journal of Pathology and Microbiology - December 31, 2019 Category: Pathology Authors: Jain P, Wadhwa N, Joshi MK, Jain M, Halder A, Mishra K Tags: Indian J Pathol Microbiol Source Type: research

The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target.
Authors: Zheng HC, Liu JJ, Li J, Wu JC, Yang L, Zhao GF, Zhao X, Jiang HM, Huang KQ, Li ZJ Abstract Down-regulated parafibromin is positively linked to the pathogenesis of parathyroid, lung, breast, ovarian, gastric and colorectal cancers. Here, we found that wild-type (WT) parafibromin overexpression suppressed proliferation, tumor growth, induced cell cycle arrest and apoptosis in colorectal cancer cells (p<0.05), but it was the converse for mutant-type (MT, mutation in nucleus localization sequence) parafibromin (p<0.05). Both WT and MT transfectants inhibited migration and invasion, and caused better diff...
Source: Oncotarget - February 24, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection
ConclusionsOur findings suggest that the SCC method is a simple, safe, and effective approach for preventing delayed bleeding after gastric ESD.
Source: Gastric Cancer - September 28, 2018 Category: Gastroenterology Source Type: research

Correction to: The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection
The article “The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection”, written by Motoi Azumi, Manabu Takeuchi, Youhei Koseki, Masaru Kumagai, Yoko Kobayashi, Masafumi Takatsuna, Aiko Yoshioka, Seiichi Yoshikawa, Tsutomu Miura, and Shuji Te rai, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 28 September 2018 without open access.
Source: Gastric Cancer - April 23, 2019 Category: Gastroenterology Source Type: research

Cancers, Vol. 15, Pages 900: Primary Tumor Resection for Metastatic Colorectal, Gastric and Pancreatic Cancer Patients: In Search of Scientific Evidence to Inform Clinical Practice
anluca Masi Giuseppe Aprile The management of the primary tumor in metastatic colorectal, gastric and pancreatic cancer patients may be challenging. Indeed, primary tumor progression could be associated with severe symptoms, compromising the quality of life and the feasibility of effective systemic therapy, and might result in life-threatening complications. While retrospective series have suggested that surgery on the primary tumor may confer a survival advantage even in asymptomatic patients, randomized trials seem not to definitively support this hypothesis. We discuss the evidence for and against primary tumor re...
Source: Cancers - January 31, 2023 Category: Cancer & Oncology Authors: Valentina Fanotto Francesca Salani Caterina Vivaldi Mario Scartozzi Dario Ribero Marco Puzzoni Francesco Montagnani Francesco Leone Enrico Vasile Maria Bencivenga Giovanni De Manzoni Debora Basile Lorenzo Fornaro Gianluca Masi Giuseppe Aprile Tags: Review Source Type: research

A Risk-prediction Model Based on Lymph-node Metastasis for Incorporation Into a Treatment Algorithm for Signet Ring Cell-type Intramucosal Gastric Cancer
Conclusions: A RSS may help to predict LNM and evaluate endoscopic submucosal dissection feasibility in patients with intramucosal SRC.
Source: Annals of Surgery - November 10, 2016 Category: Surgery Tags: Original Articles Source Type: research

Fight Aging! Newsletter, June 19th 2017
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span. Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 18, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fecal Microbiota and Its Correlation With Fatty Acids and Free Amino Acids Metabolism in Piglets After a Lactobacillus Strain Oral Administration
In conclusion, L. reuteri ZLR003 influenced the fecal microbiota composition of piglets, and its effects were related to the metabolism of SCFAs, LCFAs, and FAAs. Our findings will help facilitate the application of Lactobacillus strains in pig production. Introduction Lactobacillus, an essential member of the normal microbiota, can improve the intestinal microbial balance with beneficial effects when administered in adequate amounts (Bogovic et al., 2016; Simpson et al., 2018). Lactobacillus has been widely employed as a supplement in foods as well as in farming and medicine (Hill et al., 2014). In fact, the Lacto...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Two rare cases of synchronous and metachronous colonic metastases in patients with advanced gastric cancer
Patients with advanced gastric cancer (GC) may ultimately die because GC mostly leads to synchronous or metachronous metastasis. However, colonic metastasis of GC is extremely rare. According to a PubMed searc...
Source: World Journal of Surgical Oncology - January 31, 2018 Category: Cancer & Oncology Authors: Wei-Chih Su, Hsiang-Lin Tsai, Chun-Chieh Wu, Shan-Yin Tsai, Yung-Sung Yeh, Cheng-Jen Ma and Jaw-Yuan Wang Tags: Case Report Source Type: research

Autophagy Is a Defense Mechanism Inhibiting Invasion and Inflammation During High-Virulent Haemophilus parasuis Infection in PK-15 Cells
In this study, we sought to investigate whether SH0165 (serovar 5, high-virulent strain) and HN0001 (serovar 6, non-virulent strain) infection induces autophagy and the specific role of autophagy in bacterial invasion and inflammation during H. parasuis infection. Moreover, we explored the mechanism underlying autophagy regulated inflammation through inflammatory signaling cascades during H. parasuis infection. This observation could provide useful information for further understanding the role of autophagy in H. parasuis infection and improve our knowledge of new strategies against this pathogen. Materials and Methods B...
Source: Frontiers in cellular and infection microbiology - April 15, 2019 Category: Microbiology Source Type: research

Integrative Analyses of Long Non-coding RNA and mRNA Involved in Piglet Ileum Immune Response to Clostridium perfringens Type C Infection
In conclusion, the results improve our understanding on the characteristics of lncRNAs and mRNAs on regulating host immune response against C. perfringens type C infection, which will provide a reference for future research into exploring C. perfringens-related diseases in human. Introduction Clostridium perfringens (C. perfringens) is a Gram-positive anaerobic rod and ranks as the second most common bacteria that causes fulminant, fatal infectious and immune diseases (Scharff, 2012; Grass et al., 2013). These diseases are characterized by fever, pain, gas production, local edema, and severe tissue destruction, the...
Source: Frontiers in cellular and infection microbiology - April 30, 2019 Category: Microbiology Source Type: research